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The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might bring about a rise in methadone plasma concentrations, which could result in potentially deadly respiratory despair. In addition, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additionally